![Early life stress dysregulates kappa opioid receptor signaling within the lateral habenula - ScienceDirect Early life stress dysregulates kappa opioid receptor signaling within the lateral habenula - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S2352289520300576-fx1.jpg)
Early life stress dysregulates kappa opioid receptor signaling within the lateral habenula - ScienceDirect
![Role of RGS12 in the differential regulation of kappa opioid receptor-dependent signaling and behavior | Neuropsychopharmacology Role of RGS12 in the differential regulation of kappa opioid receptor-dependent signaling and behavior | Neuropsychopharmacology](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41386-019-0423-7/MediaObjects/41386_2019_423_Fig1_HTML.png)
Role of RGS12 in the differential regulation of kappa opioid receptor-dependent signaling and behavior | Neuropsychopharmacology
![Dynorphin-kappa opioid receptor activity in the central amygdala modulates binge-like alcohol drinking in mice | Neuropsychopharmacology Dynorphin-kappa opioid receptor activity in the central amygdala modulates binge-like alcohol drinking in mice | Neuropsychopharmacology](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41386-018-0294-3/MediaObjects/41386_2018_294_Fig1_HTML.png)
Dynorphin-kappa opioid receptor activity in the central amygdala modulates binge-like alcohol drinking in mice | Neuropsychopharmacology
![Brain opioid segments and striatal patterns of dopamine release induced by naloxone and morphine - Shokri‐Kojori - 2022 - Human Brain Mapping - Wiley Online Library Brain opioid segments and striatal patterns of dopamine release induced by naloxone and morphine - Shokri‐Kojori - 2022 - Human Brain Mapping - Wiley Online Library](https://onlinelibrary.wiley.com/cms/asset/508c4a20-6694-461b-b4f8-93eeb463264b/hbm25733-fig-0001-m.jpg)
Brain opioid segments and striatal patterns of dopamine release induced by naloxone and morphine - Shokri‐Kojori - 2022 - Human Brain Mapping - Wiley Online Library
![A systematic review on the kappa opioid receptor and its ligands: New directions for the treatment of pain, anxiety, depression, and drug abuse - ScienceDirect A systematic review on the kappa opioid receptor and its ligands: New directions for the treatment of pain, anxiety, depression, and drug abuse - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0223523422006870-gr1.jpg)
A systematic review on the kappa opioid receptor and its ligands: New directions for the treatment of pain, anxiety, depression, and drug abuse - ScienceDirect
![Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy | ACS Chemical Neuroscience Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy | ACS Chemical Neuroscience](https://pubs.acs.org/cms/10.1021/cn200128x/asset/images/medium/cn-2011-00128x_0008.gif)
Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy | ACS Chemical Neuroscience
![Design and Synthesis of a Novel and Selective Kappa Opioid Receptor (KOR) Antagonist (BTRX-335140) | Journal of Medicinal Chemistry Design and Synthesis of a Novel and Selective Kappa Opioid Receptor (KOR) Antagonist (BTRX-335140) | Journal of Medicinal Chemistry](https://pubs.acs.org/cms/10.1021/acs.jmedchem.8b01679/asset/images/medium/jm-2018-01679y_0010.gif)
Design and Synthesis of a Novel and Selective Kappa Opioid Receptor (KOR) Antagonist (BTRX-335140) | Journal of Medicinal Chemistry
![Prefrontal Cortical Kappa-Opioid Receptor Modulation of Local Neurotransmission and Conditioned Place Aversion | Neuropsychopharmacology Prefrontal Cortical Kappa-Opioid Receptor Modulation of Local Neurotransmission and Conditioned Place Aversion | Neuropsychopharmacology](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fnpp.2013.76/MediaObjects/41386_2013_Article_BFnpp201376_Fig1_HTML.jpg)
Prefrontal Cortical Kappa-Opioid Receptor Modulation of Local Neurotransmission and Conditioned Place Aversion | Neuropsychopharmacology
![Kappa‐opioid receptors differentially regulate low and high levels of ethanol intake in female mice - Van't Veer - 2016 - Brain and Behavior - Wiley Online Library Kappa‐opioid receptors differentially regulate low and high levels of ethanol intake in female mice - Van't Veer - 2016 - Brain and Behavior - Wiley Online Library](https://onlinelibrary.wiley.com/cms/asset/4f18d50a-6e44-4b32-ad1d-d3c904833b82/brb3523-fig-0001-m.jpg)
Kappa‐opioid receptors differentially regulate low and high levels of ethanol intake in female mice - Van't Veer - 2016 - Brain and Behavior - Wiley Online Library
![Nalfurafine, a G-Protein–Biased KOR (Kappa Opioid Receptor) Agonist, Enhances the Diuretic Response and Limits Electrolyte Losses to Standard-of-Care Diuretics | Hypertension Nalfurafine, a G-Protein–Biased KOR (Kappa Opioid Receptor) Agonist, Enhances the Diuretic Response and Limits Electrolyte Losses to Standard-of-Care Diuretics | Hypertension](https://www.ahajournals.org/cms/asset/89dcd157-b34a-40c1-b8f1-fd1ddd994952/hypertensionaha.121.18503.fig07.jpg)
Nalfurafine, a G-Protein–Biased KOR (Kappa Opioid Receptor) Agonist, Enhances the Diuretic Response and Limits Electrolyte Losses to Standard-of-Care Diuretics | Hypertension
![Frontiers Publishing Partnerships | Mechanisms Underlying the Anti-Suicidal Treatment Potential of Buprenorphine Frontiers Publishing Partnerships | Mechanisms Underlying the Anti-Suicidal Treatment Potential of Buprenorphine](https://www.frontierspartnerships.org/files/Articles/10009/adar-01-10009-HTML-r4/image_m/adar-01-10009-g001.jpg)
Frontiers Publishing Partnerships | Mechanisms Underlying the Anti-Suicidal Treatment Potential of Buprenorphine
![Molecules | Free Full-Text | Solving an Old Puzzle: Elucidation and Evaluation of the Binding Mode of Salvinorin A at the Kappa Opioid Receptor Molecules | Free Full-Text | Solving an Old Puzzle: Elucidation and Evaluation of the Binding Mode of Salvinorin A at the Kappa Opioid Receptor](https://pub.mdpi-res.com/molecules/molecules-28-00718/article_deploy/html/images/molecules-28-00718-ag.png?1673609615)
Molecules | Free Full-Text | Solving an Old Puzzle: Elucidation and Evaluation of the Binding Mode of Salvinorin A at the Kappa Opioid Receptor
![Will peripherally restricted kappa‐opioid receptor agonists (pKORAs) relieve pain with less opioid adverse effects and abuse potential? - Albert‐Vartanian - 2016 - Journal of Clinical Pharmacy and Therapeutics - Wiley Online Library Will peripherally restricted kappa‐opioid receptor agonists (pKORAs) relieve pain with less opioid adverse effects and abuse potential? - Albert‐Vartanian - 2016 - Journal of Clinical Pharmacy and Therapeutics - Wiley Online Library](https://onlinelibrary.wiley.com/cms/asset/3f21f1c4-4de7-4131-af58-bb484abd6473/jcpt12404-toc-0001-m.jpg?trick=1678046635786)
Will peripherally restricted kappa‐opioid receptor agonists (pKORAs) relieve pain with less opioid adverse effects and abuse potential? - Albert‐Vartanian - 2016 - Journal of Clinical Pharmacy and Therapeutics - Wiley Online Library
![The Role of Dynorphin and the Kappa Opioid Receptor in the Symptomatology of Schizophrenia: A Review of the Evidence - ScienceDirect The Role of Dynorphin and the Kappa Opioid Receptor in the Symptomatology of Schizophrenia: A Review of the Evidence - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0006322319313794-gr1.jpg)
The Role of Dynorphin and the Kappa Opioid Receptor in the Symptomatology of Schizophrenia: A Review of the Evidence - ScienceDirect
![Pharmaceuticals | Free Full-Text | In Vitro, In Vivo and In Silico Characterization of a Novel Kappa-Opioid Receptor Antagonist Pharmaceuticals | Free Full-Text | In Vitro, In Vivo and In Silico Characterization of a Novel Kappa-Opioid Receptor Antagonist](https://www.mdpi.com/pharmaceuticals/pharmaceuticals-15-00680/article_deploy/html/images/pharmaceuticals-15-00680-g001-550.jpg)
Pharmaceuticals | Free Full-Text | In Vitro, In Vivo and In Silico Characterization of a Novel Kappa-Opioid Receptor Antagonist
Conformational Constraint between Aromatic Residue Side Chains in the “Message” Sequence of the Peptide Arodyn Using Ring Closing Metathesis Results in a Potent and Selective Kappa Opioid Receptor Antagonist | Journal of
![Kappa Opioid Receptor Ligands and Pharmacology: Diphenethylamines, a Class of Structurally Distinct, Selective Kappa Opioid Ligands | SpringerLink Kappa Opioid Receptor Ligands and Pharmacology: Diphenethylamines, a Class of Structurally Distinct, Selective Kappa Opioid Ligands | SpringerLink](https://media.springernature.com/lw685/springer-static/image/chp%3A10.1007%2F164_2020_431/MediaObjects/500126_1_En_431_Fig1_HTML.png)